LIPONORM

Liponorm 10 mg: Each tablet contains: Atorvastatin calcium trihydrate: 10.85 mg.
Liponorm 20 mg: Each tablet contains: Atorvastatin calcium trihydrate: 21.70 mg.
Liponorm 40 mg: Each tablet contains: Atorvastatin calcium trihydrate: 40 mg.

Liponorm (Atorvastatin) is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts HMG-coenzyme A to mevalonate, a precursor of sterols, including cholesterol. Cholesterol and triglycerides circulate in the bloodstream as part of lipoprotein complexes. With ultracentrifugation, these complexes separate into HDL (high-density lipoprotein), IDL (intermediate-density lipoprotein), LDL (low-density lipoprotein), and VLDL (very-low-density lipoprotein) fractions. Triglycerides (TG) and cholesterol in the liver are incorporated into VLDL and released into the plasma for delivery to peripheral tissues. LDL is formed from VLDL and is catabolized primarily through the high-affinity LDL receptor. Clinical and pathologic studies show that elevated plasma levels of total cholesterol (total-C), LDL-cholesterol (LDL-C), and apolipoprotein B (apo B) promote human atherosclerosis and are risk factors for developing cardiovascular disease, while increased levels of HDL-C are associated with a decreased cardiovascular risk.



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